@article { author = {Farrokhzad, H. and Mobedi, H. and Barzin, J. and Poorkhalil, A.}, title = {Evaluation of Polymer Concentration Effect on Doxycycline Hyclate Drug Release from in SituForming System based on Poly(lactide-co-glycolide)}, journal = {Iranian Journal of Polymer Science and Technology}, volume = {22}, number = {6}, pages = {495-505}, year = {2009}, publisher = {}, issn = {10163255}, eissn = {20080883}, doi = {10.22063/jipst.2009.718}, abstract = {In this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. These systems based on poly()lactide-co-glycolide)(50:50 dissolved in N-methyl-2-pyrrolidone that were evaluated in different concentrations. These systems are useful for local treatment of periodontal diseases. UV spectroscopy is used to determine drug concentration in release medium. Also, a new method to stabilize drug in release medium was developed. The structure of prepared membranes is explained by scanning electron microscopy ()SEM) to evaluate the surficial and cross-sectional structures of polymer matrices. With increasing in polymer concentration, surface porosity decreased, membrane structure became denser, burst decreased and drug release time increased.}, keywords = {drug release,doxycycline hyclate,in situ forming,poly ()lactide-co-glycolied)(,polymer concentration}, title_fa = {بررسی اثر غلظت پلیمر بر رهایش داروی داکسی سایکلین هیکلیت از سامانه تشکیل شونده درمحل بر پایه پلی (لاکتید-کو- گلیکولید)}, abstract_fa = {}, keywords_fa = {}, url = {http://jips.ippi.ac.ir/article_718.html}, eprint = {http://jips.ippi.ac.ir/article_718_22d32824166fed37f064c7786d5c9426.pdf} }