پژوهشگاه پلیمر و پتروشیمی ایران با همکاری انجمن پلیمر ایران مجله علوم و تکنولوژی پلیمر 10163255 20 3 2007 08 23 Design and Fabrication of Biodegradable Porous Chitosan/Gelatin/Tricalcium Phosphate Hybrid Scaffolds for Tissue Engineering طراحی و ساخت داربست‌های هیبریدی متخلخل زیست‌تخریب‌پذیر بر پایه کیتوسان-ژلاتین-تری‌فسفات کلسیم برای مهندسی بافت 297 308 807 10.22063/jipst.2007.807 FA یوسف محمدی حمید میرزاده فتح اله مضطرزاده مسعود سلیمانی اسماعیل جباری Journal Article 2013 03 05 In this study, based on a biomimetic approach, novel 3D biodegradable porous hybrid scaffolds consisting of chitosan, gelatin, and tricalcium phosphate were developed for bone and cartilage tissue engineering. Macroporous chitosan/ gelatin/β-TCP scaffolds were prepared through the process of freeze-gelation/solid-liquid phase separation. The results showed that the prepared scaffolds are highly porous, with porosities larger than 80%, and have interconnected pores. Biocompatibility studies were successfully performed by in vitro and in vivo assays. Moreover, the attachment, migration, and proliferation of chondrocytes on these unique temporary scaffolds were examined to determine their potentials in tissue engineering applications. http://jips.ippi.ac.ir/article_807_07857dcb147a51ca9f65ee698d76230d.pdf