Titanium dioxide (TiO₂)-embedded polyvinylidene fluoride (PVDF) mixed matrix membranes were prepared through a nonsolvent induced phase separation (NIPS) method. The structure of the membranes was characterized by FESEM, EDX, water drop contact angle measurement, pure water flux and mean pore radius analysis. The results showed that the prepared membranes had asymmetric structures with macro-voids and the presence of TiO₂ nanoparticles increased the size of macro-voids. Moreover, pure water flux increased from 41 kg/m2h to 162 kg/m²h the content of TiO2 nanoparticles increased from 1 wt% to 5 wt% as embedded membrane. The contact angle dropped from 100° for 1 wt% TiO₂- embedded membrane to 69° for 5 wt% TiO₂-embedded membrane, showing that the hydrophilicity of membranes increased by addition of inorganic TiO₂ nanoparticles. The fouling behavior oftheprepared mixed matrix membranes was studied in filtration process of 1% humic acid solution. The results showed that fouling resistance of the membranes increased with higher content of TiO₂ nanoparticles. The results of classic fouling modeling of membranes showed that for 2 and 5 wt% TiO₂-embedded membranes the best fit of the data occurred with the intermediate blockage model whereas cake formation model was the dominant mechanism for other membranes. Moreover, the analysis of fouling mechanisms by combined models showed that cake filtration-intermediate blockage model was in good agreement with the experimental data for all membranes. Finally, the results showed that the rejection of membranes increased with the addition of TiO₂ nanoparticles, and then decreased.