An Overview on Synthesis and Functionalization of Mesoporous Silica and Its Application in Drug Delivery

Document Type : Review

Authors

Polymer Chemistry Group, Department of Chemistry, Faculty of Science, Tehran University, P.O. Box: 14155-6455, Tehran, Iran

Abstract

Nanotechnology has a prominent potential in biomedical and biomedicine applications. Especially, owing to their exclusive characteristics, hybrid nanocompounds have been recently considered as promising systems for imaging and therapeutic usages. Study on silica-based mesoporous silica materials as drug delivery systems has been considerably developed over the recent few years due to the excellent versatility and stability of these mesoporous materials. In this review, the advanced developments in synthesis, functionalization and application of mesoporous silica in drug delivery are introduced. The first section consists of three main methods, grafting, co-condensation, and periodic mesoporous organosilicates. In the next part, new approaches for functionalization of mesoporous silica in order to control drug delivery are explained. The superiority of mesoporous nannoparticles for numerous drug delivery applications are also summarized. Different mesoporous silica structures can be designed by various chemical methods to meet the drug delivery requirements. The accessible channels in mesoporous which may act as reservoirs for storing drugs can be opened and closed by different systems and create stimuli-responsive release carriers. This review focuses on intelligent nanomaterials based on mesoporous silica which can be stimulated by chemical or biological signals, such as pH, temperature, light, magnetic field and enzymes.

Keywords

Iranian Journal of Polymer Science and Technology
Volume 29, Issue 3 - Serial Number 3
July and August 2016
Pages 201-229

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