Physicomechanical Properties, Release Behavior and Cell Proliferation of PVA/Agar/PEG Hydrogel Containing Aloe Vera

Document Type : Research Paper

Authors

1 Department of Textile and Polymer Engineering, Yazd Branch, Azad University, P.O. Box 89158-13135, Yazd, Iran

2 Department of Chemical and Polymer Engineering, Faculty of Engineering, Yazd University, P.O. Box 89195-741, Yazd, Iran

Abstract

Hypothesis: Loading of herbal drug within the polymer hydrogel matrix significantly improves its performance as wound dressing. In this way, the drug amount loaded into the hydrogel plays a key role and can influence the physicomechanical properties, drug release behavior, and cell proliferation of hydrogel.
Methods: Hydrogels based on poly(vinyl alcohol) (PVA)/agar/poly(ethylene glycol) (PEG) containing various amounts (0, 0.2, 0.5, 1 and 2% by wt) of aloe vera were prepared by electron beam irradiation method at a dose of 25 kGy and keeping their water solution under the ambient atmosphere. The effect of aloe vera amount on the gel content, equilibrium swelling degree, dehydration and tensile mechanical properties of hydrogel along with aloe vera release behavior from the hydrogel and fibroblast cell proliferation was investigated.
Findings: The results obtained from the measurements indicated that with increasing aloe vera content from 0.2 wt% to 1 wt%, the gel content decreased from 55 to 47%, and the swelling degree increased from 195 to 294%. Unexpectedly, the incorporation of aloe vera to 1 wt% into the hydrogel enhanced its tensile strength by 30%, and its elongation-at-break by 119%. The dehydration phenomenon of the hydrogel was notably accelerated in the presence of aloe vera. The release kinetics of aloe vera from the hydrogel showed linear behavior and the highest release rate and amount (about 70%) was obtained for the hydrogel containing 1 wt% aloe vera. The proliferation of fibroblast cells was also the most for the hydrogel with 1 wt% aloe vera. Finally, based on the results of studies, the optimal amount of aloe vera in hydrogel was determined to be 1 wt%.


Keywords

References

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Iranian Journal of Polymer Science and Technology
Volume 34, Issue 1 - Serial Number 171
May and June 2021
Pages 69-80

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