Functionality Effect of Acrylic Pressure Sensitive Adhesive Formulations on Release Performance and Adhesion Properties of Stimulants in
an Adhesive Patch
Drug-in-adhesive transdermal drug delivery systems )TDDSs) containing stimulants, termed as energetic substances, such as caffeine and pantothenic acid, were studied. Caffeine is a white crystalline substance and a stimulant to central nervous system. In humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. Pantothenic acid, also recognized as vitamin B5, is a water-soluble vitamin. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize and metabolize proteins, carbohydrates and fats. For this purpose caffeine and pantothenic acid were used as drug components with 6.32% and 1.12% loadings, in different functional and non-functional acrylic pressure sensitive adhesives (PSAs) of 52.89%, respectively. Ethylene glycol as a chemical enhancer was used in all TDDSs with 39.67%. The effect of PSAs type on in vitro release and adhesion properties (peel strength and tack values) from drug delivery devices were evaluated. It was found that TDDS containing -COOH functional PSA showed the lowest steady state fux. The adhesion properties of the samples were improved by addition of functional acrylic PSA in formulations.