Dynamic Parameters in Preparing Chitosan Nanoparticles with Incorporation Method Using Novel Drug Delivery Systems
Polymeric nanoparticles with biodegradable and biocompatible polymers are good candidates in peptide drugs delivery systems. In this study, we success- fully prepared chitosan nanoparticles including salicylic acid as a model drug by emulsion cross-linking "in oil" method. The various dynamic parameters are considered, including the speed of stirrer, the duration of injecting the aqueous phase into oil phase and the condition of precipitation of particles. It is found that the optimum conditions are achieved at 2000 rpm when the aqueous phase is added within 30 min into the oil phase. According to optimum conditions the nanoparticles of chitosan (the peak of size distribution in 100 nm) were prepared and the drug content and the release behavior were estimated. The results demonstrate, that the drug content of nanoparticles is 35% (w/w). The release behavior of nanoparticles during first 4 hour conform best to Higuchi model and thereafter up to maximum 48 h the amount of drug released is negligible.
کلیدواژه ها [English]
novel drug delivery systems, chitosan, nanoparticle, emulsion crosslinking, salicylic acid